ENGINEERING APTAMER-DIRECTED PHOSPHATASE RECRUITING CHIMERAS: A STRATEGY FOR MODULATING RECEPTOR FUNCTION AND OVERCOMING DRUG RESISTANCE

Engineering aptamer-directed phosphatase recruiting chimeras: a strategy for modulating receptor function and overcoming drug resistance

Abstract Receptor tyrosine kinases (RTKs) play a crucial role in the regulation of intracellular signal transduction, underscoring their significance as targets for drug therapy.Despite the widespread clinical use of kinase inhibitors, the increasing occurrence of off-target effects and drug resistance makes WARNING SHOT CITRUS it urgent to explore

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Vertical Slowness-Constrained Joint Anisotropic Parameters and Event-Location Inversion for Downhole Microseismic Monitoring

The construction of accurate anisotropic velocity models is essential for effective microseismic monitoring in hydraulic fracturing.Ignoring anisotropy can result in significant distortions in microseismic event locations and their interpretation.Although methods exist to simultaneously invert anisotropic parameters and event locations using micros

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How does the British Soft Drink Association respond to media research reporting on the health consequences of sugary drinks?

Abstract Background Sugar-sweetened beverages (SSBs) are the leading global source of added sugar intake and their consumption is associated with negative health outcomes, such as diabetes, cancers, cardiovascular diseases, and overall mortality.Despite consensus within the public health community about the need to reduce sugar intake, the non-alco

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Redefining those subtle borders: transhumanism, frontiers, retroprogression and hermeneutics at the crossroads of teaching

The field of education is undergoing significant transformations, which implies that valuable views from the past may be completely overlooked in the rapid progress we are experiencing.Transhumanism, as a prevailing ideology, appears to imply an advancement at an ever-increasing speed.An interesting prospect would Toothpaste be to reflect on transh

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